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KMID : 0854720040240020257
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Korean Journal of Asthma, Allergy and Clinical Immunology
2004 Volume.24 No. 2 p.257 ~ p.260
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A Case of Anaphylaxis Due to Raw Octopus variabilis
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Kim Jeong-Eun
Choi Jeong-Hee
Suh Yu-Jin
Yoon Sung-Ho
Ye Young-Min
Shin Yu-Sub
Suh Chang-Hee
Nahm Dong-Ho
Park Hae-Sim
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Abstract
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Objective: Several studies suggest that serum total IgE (tIgE) level tended to be higher in ASA-intolerant asthma (AIA) than in other types of non-atopic asthma, whether they are atopics or non-atopics. A pathogenic role of superantigens was suggested in inflammatory responses of upper respiratory allergy with increased IgE production. To investigate a role of staphylococcal superantigens in AIA, we measured serum specific IgE level to three staphylococcal superantigens (SEA, SEB, TSST-1) in the sera of ASA- tolerant asthma (AIA), ASA tolerant asthma (ATA) patients, and normal control (NC). Method: Fifty-six AIA patients showing positive responses on L-ASA bronchoprovocation test, 40 ATA, and 30 non- atopic healty controls were enrolled. Serum specific IgE to three staphylococcal superantigens were measured by CAP system (Pharmacia, Uppsala, Sweden). Result: The prevalences of specific IgE to each superantigens were highest in AIA, followed by ATA and NC. Significanct differences were noted in the prevalence of IgE to TSST-1 and SEB between AIA and NC (P＜0.05, respectively). Serum total IgE levels were significantly higher in superantigen-positive AIA patients (P＜0.05, respectively). Furthermore, in non-atopic AIA patients, those with TSST-1 specific IgE had significantly higher total IgE levels (P＜0.05, respectively). There were no correlations between superantigen-specific IgE level and sex, atopy status or presence of urticaria. Significant correlations were found between specific IgE to SEB or TSST-1 and serum total IgE level (r=0.42, 0.30, P＜0.05), and specific IgE to TSST-1 and PC20 methacholine (r=-0.36, P＜0.05). No significant correlations were found between superantigen-specific IgE and serum soluble CD30 level or cumulative dose of L-ASA inhaled. Conclusion: Superantigen may contribute to increase in serum total IgE level, in particular, significant association with TSST-1 was noted in non-atopic AIA patients. Further studies will be needed to investigate how they contribute to AIA pathophysiology. (Korean J Asthma, Allergy Clin Immunol 2004;24:247-252)
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KEYWORD
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Octopus, Anaphylaxis, Mast cell
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Listed journal information
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